Re-Evaluating the Mechanism of Action of α,β-Unsaturated Carbonyl DUB Inhibitors b-AP15 and VLX1570:

Congratulations to Jenny & Adan on their work on covalent inhibitors of DUBs now published in J. Med. Chem.

This has been a great collaboration between the labs of Ed Tate, Benedict Kessler, Olivier Feron, and the Huber group.