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Re-Evaluating the Mechanism of Action of α,β-Unsaturated Carbonyl DUB Inhibitors b-AP15 and VLX1570:

Congratulations to Jenny & Adan on their work on covalent inhibitors of DUBs now published in J. Med. Chem.


https://pubs.acs.org/doi/10.1021/acs.jmedchem.0c00144


This has been a great collaboration between the labs of Ed Tate, Benedict Kessler, Olivier Feron, and the Huber group.


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We are looking for two enthusiastic postdoctoral fellows with expertise in structural biology to join us in our effort to study the function of proteins involved in #ubiquitination & #RNAmetabolism -

Great news: we have an open position for a PostDoc in structural biology/ biochemisrty. We would love to welcome you to our team, please apply here.

Congratulations to Ruth, @MonikaGullerova & team on their new paper @CellReports showing how RNA transcribed during DSB repair disrupts the interaction between TIRR (NUDT16L1) and 53BP1! Glad we could

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