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Dr Kilian Huber

Principal Investigator

Dr. Kilian V. M. Huber received his doctorate in Medicinal and Pharmaceutical Chemistry from the Ludwig-Maximilians-Universität (LMU) in Munich working on the design and synthesis of natural product-inspired kinase inhibitors in the group Prof. Franz Bracher. After postdoctoral studies in the laboratory of Prof. Stephen G. Davies at the Department of Chemistry, University of Oxford, and in the laboratory of Prof. Giulio Superti-Furga at the Research Centre for Molecular Medicine (CeMM), Vienna, he joined the SGC in 2015 as Principal Investigator and Chemical Biology Group Leader. In 2014 he was selected as a Winner of the GSK Discovery Fast Track Challenge, his other awards include the 2015 Young Investigator Award of the German Pharmaceutical Society (DPhG-Stiftung/Horst-Böhme-Stiftung) as well as a ThermoFisher TMT Research Award in 2017.


Laura Díaz Sáez


Dr Laura Diaz Saez completed her Biochemistry degree at the Autonomous University of Madrid and obtained her PhD from the University of Dundee working on the assessment of potential antibacterial drug targets. She joined the Huber lab to work on the structural and biochemical characterisation of novel targets involved in cancer and inflammatory disorders.


Felix Feyertag


Dr Felix Feyertag completed his Bachelor of Science in Computer Science at the University of Edinburgh. He then pursued education at the University of Manchester, first with a Master of Science in Computational Molecular Biology under supervision of Dr. Simon Whelan, followed by a PhD under supervision of Prof. David Robertson, investigating lentiviruses in the context of host adaptation as well as the emergence of drug resistance. Felix completed a postdoc at the University of Nevada, Reno, under supervision of Dr. David Alvarez-Ponce, using large-scale comparative genomic and bioinformatic approaches to investigate the fundamental causes underlying the evolution of protein-coding genes. Felix joined the Huber lab in 2018 as a bioinformatician employing chemoproteomic and systems biological methods for identifying novel drug targets for multiple myeloma.


Brigitt Raux


Originally from France, Dr. Brigitt Raux completed her Master’s degree in Functional and Structural Biology at the University of Toulouse. During her Masters she completed two internships at the Mourey group in the Institute of Pharmacology and Structural Biology in Toulouse (IPBS). Her research focused on the biochemical and structural characterization of two targets involved in the virulence of Mycobacterium tuberculosis. She then worked one year at the EIPL laboratory in Marseille, on the development of inhibitors targeting digestive enzymes implicated in obesity. Brigitt later obtained her PhD in Structural Biochemistry at the University of Aix-Marseille under the supervision of Dr. Xavier Morelli in the Centre of Research in Cancerology of Marseille (CRCM). Here, she worked on the development of potent and selective inhibitors targeting the BET family of Bromodomains. In June 2018, Brigitt joined the Huber group at the Target Discovery Institute where her current research focuses on the structural and biochemical characterisation of novel targets involved in cancer and inflammatory disorders.


Jenny Ward


Dr Jenny Ward completed her first degree (MChem) in Chemistry at the University of Oxford in 2011, having completed her Masters research in the synthesis and biological evaluation of non-inositol based ligands for the IP3 receptor under the supervision of Dr Stuart Conway. From 2011 to 2016 she undertook an MRes and PhD in Chemical Biology at the ICB-CDT, Imperial College London. Under the supervision of Prof Ed Tate and Prof Eric Lam, her research involved the design and proteomic profiling of activity-based probes for studying cellular ubiquitination machinery. Jenny also undertook a collaborative project with MISSION Therapeutics, which focussed of the chemoproteomic profiling of deubiquitinating enzymes. In June 2016 Jenny joined the Chemical Biology group at the Target Discovery Institute, where her research focuses on proteomic strategies for target identification, working in various biological and disease relevant models. Techniques utilised include thermal stability profiling, activity based protein profiling, photo affinity profiling and affinity enrichment. Jenny is also a member of Discovery Proteomics Facility, where she is responsible for the maintenance and operation of a Q-Exactive Orbitrap LC-MS/MS instrument.


Jakub Stefaniak

SABS-CDT D Phil student (joint with the Department of Chemistry)

Jake Stefaniak completed his undergraduate degree in biochemistry at the University in Oxford in 2015, with his Master’s thesis concerning cell signalling in circadian rhythms. He is now working towards his D Phil as a Systems Approaches to Biomedical Sciences (SABS) Doctoral Training Centre student under the joint supervision of Dr Kilian Huber and Prof Angela Russell. Jake’s current work revolves around the development of target deconvolution strategies using chemoproteomics and thermal stability profiling. In addition, Jake is the president of the Oxford University Scientific Society.


Elisabeth Mira Rothweiler

D Phil student

Mira Rothweiler completed her degree in Pharmacy at the Ludwig Maximilians Universität München in 2018. Before obtaining her German Pharmacy license in 2019, she gained practical experience as a pharmaceutical intern at the Adler Apotheke in Hamburg. For six months, she worked in the Huber group at the University of Oxford where she synthesised bifunctional degraders and subsequently tested them in cellular assays. In October 2019 Mira started her research project as an NDM studentship DPhil candidate. Currently, she is investigating new approaches for targeted protein degradation and ligand-based screening under co-supervision of Dr Kilian Huber and Prof Paul Brennan.


Jiangpeikun Song

D Phil student

Jiangpeikun Song obtained his BS degree in Biology at Tsinghua University in 2019, with his thesis focusing on fluorescence polarization microscopy. After finishing his Bachelor's degree, he joined the Huber group in October 2019 as a DPhil student. Currently he is working on identifying E3 ligase targets using proximity-labelling based approaches.


Catherine Rogers

Research Assistant

Dr Catherine Rogers completed her degree in Biochemistry degree at the University of Warwick and then undertook a PhD with AstraZeneca and the University of Nottingham, in the School of Pharmacy. She then spent two years working as a postdoctoral research associate in the EPSRC Centre for Innovative Manufacturing in Regenerative Medicine at the University of Nottingham, before joining the SGC in 2013. Her work comprises of establishing and running cellular target engagement assays.


Paul Smith

Research Assistant

Dr Paul Smith completed his PhD in the Department of Biochemistry at the University of Leicester working on characterising the early spliceosomal complexes in the lab of Dr Olga Makarova. He then moved to the lab of Dr Andrey Revyakin making endogenously tagged transcription factors using CRISPR-CAS9 genome editing. Paul joined the Huber group in 2017 to work on CRISPR and genome-editing for drug target validation and cellular target engagement.


Sun Jung

Laboratory Technician

Sun Jung completed her degree in Biochemistry at the University of Leicester in 2016. During her final year project, she was investigating the interactions between CSN5 and its binding proteins in the Structural Biology of Cancer-Related Protein Targets group. After graduation, she was part of a disease model development team in Chronos Therapeutics working on drug screening and model validation for motor neuron disease. She joined the Huber group in 2018 and is working on protein production to support biochemical and structural characterisation of novel targets.


Anne-Sophie Marques


Dr. Anne-Sophie Marques completed her Bachelor in Chemistry at the University of Versailles in France and her Master in Chemistry and Organic Chemistry at the University of Paris Sud. She then entered the École Nationale Supérieure de Chimie de Paris where she graduated in 2015 with a dual Master degree in Molecular Chemistry from Pierre and Marie Curie University.
During her studies, she undertook several research internships in medicinal chemistry and organic synthesis at Sanofi in Chilly Mazarin, Roche in Basel and the CNRS in Versailles.
She then pursued her PhD in Chemistry at the University of Paris Saclay where she worked on the development of new domino reactions for the synthesis of polycyclic compounds under the supervision of Pr. X. Moreau. She left France for Newcastle University in January 2019 to work as a Postdoctoral Researcher on the development of new anticancer agents under the guidance of Dr. C. Cano. She started a new Postdoctoral Researcher position in the Huber lab in April 2021 to work on the development of new degraders for cancer research.


Jesper Hansen


Dr Jesper S. Hansen is a biomedical and biophysical research scientist specialising in the biology and targeting of integral membrane proteins, as well as proteins interacting with cellular lipid membranes. Jesper completed his degree in biomedicine (MSc) at the University of Southern Denmark and did his PhD with the Danish biotech company Aquaporin A/S and Technical University of Denmark, DTU Nanotech. He has since worked as a postdoctoral researcher at University of Copenhagen (DK), University of Southern California (US) and Lund University (SE) before joining University of Oxford (UK) in 2019. His work comprises of establishing and running biochemical and biophysical analyses of proteins including solute carrier target engagement assays.


Srinivasa Rao Adusumalli


Dr Srinivasa Rao Adusumalli obtained his Master of Science in Organic Chemistry from Acharya Nagarjuna University (India). During his Ph.D. in Chemistry under the supervision of Dr. Vishal Rai at the Indian Institute of Science Education and Research (IISER Bhopal, India), he developed chemical technologies for single-site labeling of native proteins. Later he joined “Plabeltech Private Limited” (India) and was involved in developing the toolbox for precision labeling of antibodies. As a Marie Curie Postdoctoral Fellow in the Prof. Bernardes group at University of Cambridge (UK), he developed covalent small molecules for redesigning the structure and function of biomolecules and enabling the degradation of target protein. In April 2022, he joined the Dr. Huber group as Oxford-BMS Fellow at Nuffield Department of Medicine, University of Oxford. He is currently working on the development of new tools for systematic profiling of E3 ligase complexes with small molecule modulators.


Usha Singh


I completed my Master of Science in Biotechnology from Banasthali University, India, after which I joined Nucleoporin & Sumo Biology Group at Indian Institute of Science Education and Research, Bhopal (India) for PhD. During my PhD I worked to delineate the relation between nucleoporin over expression and mechanistic role in cancer. In addition to this I also worked to investigate the biological functionality of protein modification and drug modification chemistry. I then worked as a postdoctoral fellow in a collaborative project at National Centre for Cell Science, Pune India and Bharat Biotech International Limited, Hyderabad, India where we generated human neutralising monoclonal antibodies against SARS-CoV2. I joined Huber group in March 2022 as postdoctoral scientist in an exciting and translational project with Cancer Research UK and Merck. I will be working to elucidate the molecular dynamics of transcriptional complexes in cancer to develop novel drug targets.


Ludwig Bauer

 D Phil student

Ludwig studied biochemistry at the Technical University in Munich (Germany).  During this time, he participated in iGEM’17, an international student competition in synthetic biology, as member of the joint team of both Munich universities. Interested in chemical biology, he joined the Cravatt group at the Scripps Research Institute in San Diego (USA) as a visiting student, for which he was supported by an Otto-Bayer scholarship. Subsequently, he completed an internship at Roche in Basel (Switzerland) developing a LC-MS method for quality assessment of therapeutic antibodies. For his master thesis project he joined the Superti-Furga lab at the Center for Molecular Medicine (Austria) where his work focused on characterizing protein-protein interactions involving transporters of the Solute Carrier family by MS-based proteomic approaches. Currently he is working towards a DPhil as part of the Chemistry in Cells doctoral programme - co-supervised by Dr Kilian Huber and Prof Michael Willis.


Jeppe Tranberg-Jensen

Research Assistant

Jeppe completed his Bachelor and Master degree in Molecularbiology at Aarhus University(Denmark). During his master thesis, Jeppe developed and optimised a method of spatiotemporal loss of function in mice and celllines, to accelerate the understanding of protein function in memory. In our group, Jeppe is working as a Research Assistant, developing high throughput cellular assays for drug discovery.

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Carol Cheng

Research Assistant

Dr. Cheng Lai Hung Carol completed her Bachelor in Biochemistry at the Hong Kong University of Science and Technology with first-class honour and her MPhil in Biomedical Sciences at the Chinese University of Hong Kong.
She then pursued her PhD in Pathology at the University of Hong Kong where she worked on cancer epigenetics and studied the pathological functions of bromodomain-containing proteins under the supervision of Dr. Wong Chun Ming Jack. She left Hong Kong and joined Huber lab in August 2021 as a research assistant because she is interested in drug development and industrial projects. Currently, she is working on assay development and high throughput screening.

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Nitisha Gurav

Laboratory Technician

Nitisha received her degree in Pharmacy from the Institute of Chemical Technology in Mumbai. During this time, she interned at Abbott Healthcare’s I&D department and CSIR-National Chemical laboratory. In 2020, she relocated to the United Kingdom to pursue her master's in Biotechnology at the University of Nottingham, supported by the Developing Solutions Scholarship. She used an in-silico proteomics approach to identify surface proteins in the cattle blood parasite, Theileria Parva, for her master's thesis. After graduation, she worked as a research assistant for the ONS COVID-19 surveillance project at the University of Oxford. She worked with liquid handling platforms for high-throughput ELISA screening in this position. In October 2022, she began working as a technician with protein expression and purification in the Huber group at Target Discovery Institute.

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