We are delighted to congratulate Haozhe on successfully passing his DPhil viva.
We are grateful to Professor Chris Schofield (University of Oxford) and Professor Lyn Jones (Dana-Farber Cancer Institute/Harvard Medical School) for serving as Haozhe's examiners and for their insightful and constructive feedback.
Congratulations, Haozhe, on this important milestone, and we wish you every success in the next stage of your career!
New in Nature Communications: a live-cell BRET biosensor to study how PRMT5 inhibitors engage their target in a tumour-context cellular environment
We investigated the PRMT5 inhibitor GSK3326595 and developed CBH-002, a BRET probe that binds a genetically encoded PRMT5-NanoLuc biosensor and senses changes in SAM/MTA. This enabled us to determine EC50 values in MTAP wild-type and MTAP-deleted cells, quantifying inhibitor potency in a cell-context-dependent way - adding another layer of personalised medicine
What if an enzyme you thought you knew turned out to control metabolism in a completely new way?
We found that NUDT5 acts as a molecular handbrake on purine synthesis, reshaping how cells make DNA building blocks and respond to cancer drugs.
