What if an enzyme you thought you knew turned out to control metabolism in a completely new way?
We found that NUDT5 acts as a molecular handbrake on purine synthesis, reshaping how cells make DNA building blocks and respond to cancer drugs.
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NEWS
Excited to share our latest paper out in Angewandte:
Using a phenomics-based screen, we uncovered that CHKA (choline kinase α) - a key metabolic enzyme in cancer/immune signalling - is an off-target of well-known G9a/GLP inhibitors (UNC0638/UNC0737).
📎 Paper: Phenomics-Based Discovery of Novel Orthosteric Choline Kinase Inhibitors (Angew. Chem. Int. Ed., DOI:10.1002/anie.202420149)
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