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LAB MEMBERS
Dr Kilian Huber
Principal Investigator
Dr. Kilian V. M. Huber received his doctorate in Medicinal and Pharmaceutical Chemistry from the Ludwig-Maximilians-Universität (LMU) in Munich working on the design and synthesis of natural product-inspired kinase inhibitors in the group Prof. Franz Bracher. After postdoctoral studies in the laboratory of Prof. Stephen G. Davies at the Department of Chemistry, University of Oxford, and in the laboratory of Prof. Giulio Superti-Furga at the Research Centre for Molecular Medicine (CeMM), Vienna, he joined the SGC in 2015 as Principal Investigator and Chemical Biology Group Leader. In 2014 he was selected as a Winner of the GSK Discovery Fast Track Challenge, his other awards include the 2015 Young Investigator Award of the German Pharmaceutical Society (DPhG-Stiftung/Horst-Böhme-Stiftung) as well as a ThermoFisher TMT Research Award in 2017.
Anne-Sophie Marques
Postdoc
Dr. Anne-Sophie Marques completed her Bachelor in Chemistry at the University of Versailles in France and her Master in Chemistry and Organic Chemistry at the University of Paris Sud. She then entered the École Nationale Supérieure de Chimie de Paris where she graduated in 2015 with a dual Master degree in Molecular Chemistry from Pierre and Marie Curie University.
During her studies, she undertook several research internships in medicinal chemistry and organic synthesis at Sanofi in Chilly Mazarin, Roche in Basel and the CNRS in Versailles.
She then pursued her PhD in Chemistry at the University of Paris Saclay where she worked on the development of new domino reactions for the synthesis of polycyclic compounds under the supervision of Pr. X. Moreau. She left France for Newcastle University in January 2019 to work as a Postdoctoral Researcher on the development of new anticancer agents under the guidance of Dr. C. Cano. She started a new Postdoctoral Researcher position in the Huber lab in April 2021 to work on the development of new degraders for cancer research.
Jesper Hansen
Postdoc
Dr Jesper S. Hansen is a biomedical and biophysical research scientist specialising in the biology and targeting of integral membrane proteins, as well as proteins interacting with cellular lipid membranes. Jesper completed his degree in biomedicine (MSc) at the University of Southern Denmark and did his PhD with the Danish biotech company Aquaporin A/S and Technical University of Denmark, DTU Nanotech. He has since worked as a postdoctoral researcher at University of Copenhagen (DK), University of Southern California (US) and Lund University (SE) before joining University of Oxford (UK) in 2019. His work comprises of establishing and running biochemical and biophysical analyses of proteins including solute carrier target engagement assays.
Srinivasa Rao Adusumalli
Postdoc
Dr Srinivasa Rao Adusumalli obtained his Master of Science in Organic Chemistry from Acharya Nagarjuna University (India). During his Ph.D. in Chemistry under the supervision of Dr. Vishal Rai at the Indian Institute of Science Education and Research (IISER Bhopal, India), he developed chemical technologies for single-site labeling of native proteins. Later he joined “Plabeltech Private Limited” (India) and was involved in developing the toolbox for precision labeling of antibodies. As a Marie Curie Postdoctoral Fellow in the Prof. Bernardes group at University of Cambridge (UK), he developed covalent small molecules for redesigning the structure and function of biomolecules and enabling the degradation of target protein. In April 2022, he joined the Dr. Huber group as Oxford-BMS Fellow at Nuffield Department of Medicine, University of Oxford. He is currently working on the development of new tools for systematic profiling of E3 ligase complexes with small molecule modulators.
Usha Singh
Postdoc
I completed my Master of Science in Biotechnology from Banasthali University, India, after which I joined Nucleoporin & Sumo Biology Group at Indian Institute of Science Education and Research, Bhopal (India) for PhD. During my PhD I worked to delineate the relation between nucleoporin over expression and mechanistic role in cancer. In addition to this I also worked to investigate the biological functionality of protein modification and drug modification chemistry. I then worked as a postdoctoral fellow in a collaborative project at National Centre for Cell Science, Pune India and Bharat Biotech International Limited, Hyderabad, India where we generated human neutralising monoclonal antibodies against SARS-CoV2. I joined Huber group in March 2022 as postdoctoral scientist in an exciting and translational project with Cancer Research UK and Merck. I will be working to elucidate the molecular dynamics of transcriptional complexes in cancer to develop novel drug targets.
Ludwig Bauer
D Phil student
Ludwig studied biochemistry at the Technical University in Munich (Germany). During this time, he participated in iGEM’17, an international student competition in synthetic biology, as member of the joint team of both Munich universities. Interested in chemical biology, he joined the Cravatt group at the Scripps Research Institute in San Diego (USA) as a visiting student, for which he was supported by an Otto-Bayer scholarship. Subsequently, he completed an internship at Roche in Basel (Switzerland) developing a LC-MS method for quality assessment of therapeutic antibodies. For his master thesis project he joined the Superti-Furga lab at the Center for Molecular Medicine (Austria) where his work focused on characterizing protein-protein interactions involving transporters of the Solute Carrier family by MS-based proteomic approaches. Currently he is working towards a DPhil as part of the Chemistry in Cells doctoral programme - co-supervised by Dr Kilian Huber and Prof Michael Willis.
Jeppe Tranberg-Jensen
Research Assistant
Jeppe completed his Bachelor and Master degree in Molecularbiology at Aarhus University(Denmark). During his master thesis, Jeppe developed and optimised a method of spatiotemporal loss of function in mice and celllines, to accelerate the understanding of protein function in memory. In our group, Jeppe is working as a Research Assistant, developing high throughput cellular assays for drug discovery.
Haozhe Xiao
DPhil student
Haozhe is a second year DPhil student in Clinical Medicine at the Nuffield Department of Medicine. His current research project focuses on using chemical probes to enable the functional exploration of cellular proteins with regard to their relevance for drug discovery. He is also a Gustav Born Scholar at St Peter's College. He acquired his undergraduate degree in Chemistry at University of Durham. After that, he moved to Imperial College London for his MRes program in Drug Discovery and Development. He is keen to conduct research in organic chemistry, chemical biology and drug discovery. Moreover, he has many internship experiences working as a research assistant and data analyst. In addition, he has conducted multiple voluntary work during his undergraduate studies. Apart from work, he enjoys travelling, reading and painting.
Alice Page
DPhil student
Alice completed her MChem at The University of York. During her master's year, she completed an industrial placement at Astrazeneca working in chemical development, here she attained RSci status with the RSC. Her master's research focused on the process development of a mineralocorticoid-receptor modulator, due to be used as a heart failure treatment. She worked on designing and optimising the synthetic route of an intermediate in the overall synthesis, ahead of a large-scale manufacture. She also completed an internship working as an analyst using mass spectrometry. After finishing her degree, she took a year out to travel around Southeast Asia and Australia. She is currently working towards a DPhil as part of the Chemistry in Cells doctoral programme - co-supervised by Dr Kilian Huber, Prof Paul Brennan and Dr David Hewings. Her research is focused on using high throughput chemistry to enable targeted cellular fragment screening.
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