PUBLICATIONS

SELECTED PUBLICATIONS

Small molecule inhibitors reveal an indispensable scaffolding role of RIPK2 in NOD2 signaling.

Hrdinka, M; Schlicher, L; Dai, B; Pinkas, DM; Bufton, JC; Picaud, S; Ward, JA; Rogers, C; Suebsuwong, C; Nikhar, S; Cuny, GD; Huber, KV; Filippakopoulos, P; Bullock, AN; Degterev, A; Gyrd-Hansen, M;
EMBO Journal. 2018 37:-. doi: 10.15252/embj.201899372
PMID: 30026309

 

Quantitative, Wide-Spectrum Kinase Profiling in Live Cells for Assessing the Effect of Cellular ATP on Target Engagement.

Vasta, JD; Corona, CR; Wilkinson, J; Zimprich, CA; Hartnett, JR; Ingold, MR; Zimmerman, K; Machleidt, T; Kirkland, TA; Huwiler, KG; Ohana, RF; Slater, M; Otto, P; Cong, M; Wells, CI; Berger, B-T; Hanke, T; Glas, C; Ding, K; Drewry, DH; Huber, KVM; Willson, TM; Knapp, S; Müller, S; Meisenheimer, PL; Fan, F; Wood, KV; Robers, MB;
Cell Chemical Biology. 2018 25:206-214.e11. doi: 10.1016/j.chembiol.2017.10.010
PMID: 29174542

 

Discovery of an MLLT1/3 YEATS Domain Chemical Probe.

Moustakim, M; Christott, T; Monteiro, OP; Bennett, J; Giroud, C; Ward, J; Rogers, CM; Smith, P; Panagakou, I; Saez, LD; Felce, SL; Gamble, V; Gileadi, C; Halidi, N; Heidenreich, D; Chaikuad, A; Knapp, S; Huber, KVM; Farnie, G; Heer, J; Manevski, N; Poda, G; Al-Awar, R; Dixon, DJ; Fedorov, O; Brennan, P;
Angewandte Chemie International Edition. 2018 :-. doi: 10.1002/anie.201810617
PMID: 30288907

 

Chemical Instability and Promiscuity of Arylmethylidenepyrazolinone-Based MDMX Inhibitors.

Stefaniak, J; Lewis, AM; Conole, D; Galan, SRG; Bataille, CJR; Wynne, GM; Castaldi, MP; Lundbäck, T; Russell, AJ; Huber, KVM;
ACS Chemical Biology. 2018 :-. doi: 10.1021/acschembio.8b00665
PMID: 30216042

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Target engagement: Shining a light.

Huber, KVM;
Nature Chemical Biology. 2017 13:133-134. doi: 10.1038/nchembio.2295
PMID: 28103226

 

Global survey of the immunomodulatory potential of common drugs.

Vladimer, GI; Snijder, B; Krall, N; Bigenzahn, JW; Huber, KVM; Lardeau, C-H; Sanjiv, K; Ringler, A; Berglund, UW; Sabler, M; de la Fuente, OL; Knöbl, P; Kubicek, S; Helleday, T; Jäger, U; Superti-Furga, G;
Nature Chemical Biology. 2017 13:681-690. doi: 10.1038/nchembio.2360
PMID: 28437395

 

Artemisinins Target GABAA Receptor Signaling and Impair α Cell Identity.

Li, J; Casteels, T; Frogne, T; Ingvorsen, C; Honoré, C; Courtney, M; Huber, KVM; Schmitner, N; Kimmel, RA; Romanov, RA; Sturtzel, C; Lardeau, C-H; Klughammer, J; Farlik, M; Sdelci, S; Vieira, A; Avolio, F; Briand, F; Baburin, I; Májek, P; Pauler, FM; Penz, T; Stukalov, A; Gridling, M; Parapatics, K; Barbieux, C; Berishvili, E; Spittler, A; Colinge, J; Bennett, KL; Hering, S; Sulpice, T; Bock, C; Distel, M; Harkany, T; Meyer, D; Superti-Furga, G; Collombat, P; Hecksher-Sørensen, J; Kubicek, S;
Cell. 2017 168:86-100.e15. doi: 10.1016/j.cell.2016.11.010
PMID: 27916275

 

Heme drives hemolysis-induced susceptibility to infection via disruption of phagocyte functions.

Martins, R; Maier, J; Gorki, A-D; Huber, KVM; Sharif, O; Starkl, P; Saluzzo, S; Quattrone, F; Gawish, R; Lakovits, K; Aichinger, MC; Radic-Sarikas, B; Lardeau, C-H; Hladik, A; Korosec, A; Brown, M; Vaahtomeri, K; Duggan, M; Kerjaschki, D; Esterbauer, H; Colinge, J; Eisenbarth, SC; Decker, T; Bennett, KL; Kubicek, S; Sixt, M; Superti-Furga, G; Knapp, S;
Nature Immunology. 2016 17:1361-1372. doi: 10.1038/ni.3590
PMID: 27798618

 

Proteome-wide drug and metabolite interaction mapping by thermal-stability profiling.

Huber, KVM; Olek, KM; Müller, AC; Tan, CSH; Bennett, KL; Colinge, J; Superti-Furga, G;
Nature Methods. 2015 12:1055-1057. doi: 10.1038/nmeth.3590
PMID: 26389571

 

SLC38A9 is a component of the lysosomal amino acid sensing machinery that controls mTORC1.

Rebsamen, M; Pochini, L; Stasyk, T; de Araújo, MEG; Galluccio, M; Kandasamy, RK; Snijder, B; Fauster, A; Rudashevskaya, EL; Bruckner, M; Scorzoni, S; Filipek, PA; Huber, KVM; Bigenzahn, JW; Heinz, LX; Kraft, C; Bennett, KL; Indiveri, C; Huber, LA; Superti-Furga, G;
Nature. 2015 519:477-481. doi: 10.1038/nature14107
PMID: 25561175

 

A cellular screen identifies ponatinib and pazopanib as inhibitors of necroptosis.

Fauster, A; Rebsamen, M; Huber, KVM; Bigenzahn, JW; Stukalov, A; Lardeau, C-H; Scorzoni, S; Bruckner, M; Gridling, M; Parapatics, K; Colinge, J; Bennett, KL; Kubicek, S; Krautwald, S; Linkermann, A; Superti-Furga, G;
Cell Death and Disease. 2015 6:e1767-. doi: 10.1038/cddis.2015.130
PMID: 25996294

 

Experimental characterization of the human non-sequence-specific nucleic acid interactome.

Dürnberger, G; Bürckstümmer, T; Huber, K; Giambruno, R; Doerks, T; Karayel, E; Burkard, TR; Kaupe, I; Müller, AC; Schönegger, A; Ecker, GF; Lohninger, H; Bork, P; Bennett, KL; Superti-Furga, G; Colinge, J;
Genome Biology. 2013 14:R81-. doi: 10.1186/gb-2013-14-7-r81
PMID: 23902751

 

7,8-dichloro-1-oxo-β-carbolines as a versatile scaffold for the development of potent and selective kinase inhibitors with unusual binding modes.

Huber, K; Brault, L; Fedorov, O; Gasser, C; Filippakopoulos, P; Bullock, AN; Fabbro, D; Trappe, J; Schwaller, J; Knapp, S; Bracher, F;
Journal of Medicinal Chemistry. 2012 55:403-413. doi: 10.1021/jm201286z
PMID: 22136433

 

Specific CLK inhibitors from a novel chemotype for regulation of alternative splicing.

Fedorov, O; Huber, K; Eisenreich, A; Filippakopoulos, P; King, O; Bullock, AN; Szklarczyk, D; Jensen, LJ; Fabbro, D; Trappe, J; Rauch, U; Bracher, F; Knapp, S;
Cell Chemistry Biology. 2011 18:67-76. doi: 10.1016/j.chembiol.2010.11.009
PMID: 21276940

 

Novel 3-arylideneindolin-2-ones as inhibitors of NAD+ -dependent histone deacetylases (sirtuins).

Huber, K; Schemies, J; Uciechowska, U; Wagner, JM; Rumpf, T; Lewrick, F; Süss, R; Sippl, W; Jung, M; Bracher, F;
Journal of Medicinal Chemistry. 2010 53:1383-1386. doi: 10.1021/jm901055u
PMID: 20030343

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©2019 by Huber Lab.