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Excited to share our latest paper out in Angewandte : Using a phenomics-based screen, we uncovered that CHKA (choline kinase α) - a key metabolic enzyme in cancer/immune signalling - is an off-target of well-known G9a/GLP inhibitors (UNC0638/UNC0737). 📎 Paper: Phenomics-Based Discovery of Novel Orthosteric Choline Kinase Inhibitors  (Angew. Chem. Int. Ed., DOI:10.1002/anie.202420149) #DrugDiscovery #ChemicalBiology #Metabolism #ImmuneSignalling #PhenotypicScreening