New ChemBioHub Phenomics Paper!
- kilianhuber
- Nov 6
- 1 min read
Excited to share our latest paper out in Angewandte:
Using a phenomics-based screen, we uncovered that CHKA (choline kinase α) - a key metabolic enzyme in cancer/immune signalling - is an off-target of well-known G9a/GLP inhibitors (UNC0638/UNC0737).
📎 Paper: Phenomics-Based Discovery of Novel Orthosteric Choline Kinase Inhibitors (Angew. Chem. Int. Ed., DOI:10.1002/anie.202420149)
