Congratulations to our friends at Promega & SGC-UNC who have developed a platform to comprehensively study CDK inhibitor target engagement across the whole family in live cells. Very excited we could contribute - check out the full paper now published in Nature Communications:
https://www.nature.com/articles/s41467-020-16559-0
#chemicalprobes #targetengagement #drugdiscovery #CDK
Congratulations to Jenny & Adan on their work on covalent inhibitors of DUBs now published in J. Med. Chem.
https://pubs.acs.org/doi/10.1021/acs.jmedchem.0c00144
This has been a great collaboration between the labs of Ed Tate, Benedict Kessler, Olivier Feron, and the Huber group.
Check out this blog post by industry expert Derek Lowe summarising his thoughts on covalent fragments & inhibitors which mentions some of our own recent work using crystallographic and covalent fragment screens in collaboration with the London and Brennan labs (https://pubs.acs.org/doi/10.1021/jacs.9b02822).