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Target Identification & Validation in Drug Discovery



What makes a good drug target? Technology Networks has recently featured an article highlighting some of the challenges that the Huber Lab aims to tackle.


Dr Kilian V. M. Huber states,"A good drug target needs to be relevant to the disease phenotype and should be amenable to therapeutic modulation. At the same time, you need to have a good therapeutic window to assure that any therapeutic modality aimed at the target will not cause side effects by disrupting the physiological function of the target in healthy tissue."


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We are looking for two enthusiastic postdoctoral fellows with expertise in structural biology to join us in our effort to study the function of proteins involved in #ubiquitination & #RNAmetabolism -

Great news: we have an open position for a PostDoc in structural biology/ biochemisrty. We would love to welcome you to our team, please apply here.

Congratulations to Ruth, @MonikaGullerova & team on their new paper @CellReports showing how RNA transcribed during DSB repair disrupts the interaction between TIRR (NUDT16L1) and 53BP1! Glad we could

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